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Serum retinol binding protein is more strongly associated with retinol than measures of insulin sensitivity and BMI in fasted obese adults
Author(s) -
Mills Jordan P,
Tanumihardjo Sherry A,
Furr Harold C
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.313.4
Subject(s) - retinol , medicine , endocrinology , vitamin , retinol binding protein , insulin , insulin resistance , chemistry , homeostasis
Elevated serum retinol binding protein (RBP), the major carrier of vitamin A, has been linked to obesity and type 2 diabetes, suggesting therapeutic potential in lowering blood concentrations. Obese men and women (BMI > 30) ( n = 76) were fasted for ≥ 8 hr prior to blood collection. Blood chemistries were obtained. Retinol and retinyl esters were quantified by HPLC and RBP by ELISA. The relations between serum RBP, retinol and retinyl esters as well as measures of insulin sensitivity and BMI were determined using the Pearson correlation for simple associations and multiple linear regression for multivariate models. Retinol and RBP were .0001) with a molar ratio (retinol:RBP) of 0.73 ± 0.14. RBP was not associated with BMI, glucose, insulin or the homeostatic model assessment (HOMA) ( P > 0.05), but was inversely associated with the glucose/insulin ratio (r = −0.31, P < 0.02). In multivariate models, only retinol and the glucose/insulin ratio were significant explanatory variables for RBP. Total serum retinyl ester concentration was positively associated with retinol (r = 0.30, P < 0.01) and the association was strengthened after the removal of three potentially hypervitaminotic subjects (retinyl ester ≥ 10% total retinol) from the sample (r = 0.48, P < 0.0001). When evaluating the therapeutic potential of lowering serum RBP, consequences on vitamin A metabolism should be considered.