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Glucose transporter type 2 (GLUT2) genotype is associated with higher intakes of sugars in two distinct populations
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.306.2
Subject(s) - glut2 , allele , population , type 2 diabetes , genotype , biology , medicine , food intake , endocrinology , diabetes mellitus , physiology , genetics , glucose transporter , insulin , gene , environmental health
Glucose transporter type 2 (GLUT2) has been implicated in impaired control of feeding in GLUT2‐null mice, however, its role in food intake regulation in humans is unknown. Our objective was to determine whether a genetic variation in GLUT2 (Thr110Ile) affects food intake among two distinct populations. In the first population, carriers of the Ile allele had a higher intake of sugars as assessed using 3‐day food records administered on two separate visits (visit 1: 112 ± 9 vs 86 ± 4 g/d, p=0.01; and visit 2: 111 ± 8 vs 82 ± 4 g/d, p=0.003), demonstrating within‐population reproducibility. In a second population, carriers of the Ile allele reported consuming a greater intake of sugars over a one‐month period as measured using a food frequency questionnaire (131 ± 5 vs 115 ± 3 g/d, p=0.007), and the higher consumption of sugars was proportional to the number of Ile alleles. These observations were consistent across older and younger adults as well as among subjects with mild type 2 diabetes and healthy individuals. Taken together, our findings show that a genetic variation in GLUT2 affects habitual consumption of sugars, suggesting an underlying glucose‐sensing mechanism that regulates food intake. Supported by Canadian Institutes of Health Research and Advanced Foods & Materials Network.