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Risk of severe depressive mood decreases with improving hemoglobin levels, but only when daytime salivary cortisol concentration is low
Author(s) -
Rahn Maike,
Haas Jere D,
HernándezCordero Sonia L,
Campirano Fabricio A,
Villapando Salvador,
Rivera Juan
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.304.7
Subject(s) - beck depression inventory , mood , medicine , ferritin , anemia , hemoglobin , area under the curve , major depressive disorder , transferrin saturation , depression (economics) , gastroenterology , psychology , psychiatry , iron deficiency , anxiety , macroeconomics , economics
Previous research indicates that stressor exposure increases risk of severe depressive mood in iron deficient Hispanic women (Rahn 2007). Iron status, severity of depressive mood (Beck depression inventory, BDI), and salivary cortisol concentration were assessed in 48 female Mexican factory workers from the state of Morelos. Iron status measures were hemoglobin, ferritin, protoporphyrin, MCV and transferrin saturation. Salivary cortisol was sampled as a biological marker of stress for 2 successive days. The area under the cortisol concentration curve (AUC) over 7 daytime hours was estimated. Fatigue was assessed with the Fatigue Severity Scale. Mean age was 29 years; mean hemoglobin was 131 g/L (SD=18) and ranged from 8.8 to 16.1 g/L. Anemia with iron depletion occurred in 25% of subjects, while severe depressive mood (BDI score≥29) was found in 31%. The outcome of the logistic regression analysis was risk of severe depressive mood (BDI ≥29) compared to the reference group (BDI<29). Hemoglobin (continuous) and AUC (