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Body composition and Bone Health of Obese Adolescents with vitamin D deficiency
Author(s) -
Lenders Carine,
Feldman Henry A,
Merewood Anne,
Sweeney Carol,
Wilson Darrell M,
Lee Phillip DK,
Abrams Stephanie H,
Gitelman Stephen E,
Wertz Marcia S,
Chen Tai C,
Holick Michael F
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.295.5
Subject(s) - osteocalcin , endocrinology , medicine , lean body mass , vitamin d and neurology , vitamin d deficiency , vitamin , obesity , resorption , bone resorption , chemistry , body weight , biochemistry , alkaline phosphatase , enzyme
Objectives: To evaluate body composition and bone health of obese adolescents with and without vitamin D deficiency Methods: Data from 58 out of 92 obese adolescents aged 13–17.9 years evaluated for the Glaser Metformin Trial were obtained. Bone mineral content (BMC), lean body mass, and total body fat from DXA‐scan and visceral fat from CT‐scan were measured. Vitamin D status was determined using plasma 25(OH)D and iPTH. Vitamin D deficiency was defined as 25(OH)D<20 ng/mL. Osteocalcin was used as a biomarker for bone formation and CTX for bone resorption. Mean±SD and Student t test were used for analysis. Results: Adolescents were 15±1.4 y. old, had a BMI of 36±5 kg/m 2 , 55 were Tanner Stage>2, 38 were female, and 8 were black. Their level of 25(OH)D was 25±10 ng/ml, iPTH 16±10 pg/ml, osteocalcin 45±22 ng/ml, CTX 1.5±0.9 ng/ml, and BMC 2273±402 g. A total of 17/58 were vitamin D deficient but none had high iPTH (max 48 pg/ml). The group with vs. without vitamin D deficiency had similar lean body mass (57±3 vs. 56±1 kg, p=0.77), differed in total body fat (43±1 vs. 39±1%, p=0.002), but not visceral fat (11±1 vs. 13±1%, p=0.17). They had lower osteocalcin (35±3 vs. 49±4 ng/ml, p=0.04) but similar CTX (1.2±0.2 vs.1.6±0.1 ng/ml, p=0.10) and BMC (2345±93 vs. 2243±65 g, p=0.39). Conclusion: Vitamin D deficiency was associated with fat mass and lower osteocalcin, but was not a predictor of BMC in obese adolescents.