Premium
Regulation and function of the TSC‐mTOR pathway in cell growth
Author(s) -
Guan KunLiang
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.263.1
Subject(s) - pi3k/akt/mtor pathway , mtorc1 , mtorc2 , p70 s6 kinase 1 , mechanistic target of rapamycin , microbiology and biotechnology , rptor , protein kinase b , ribosomal protein s6 , biology , signal transduction , phosphorylation , cell growth , biochemistry
The mammalian target of rapamycin (mTOR) plays a central role in the regulation of cell growth. mTOR exists in two distinct complexes, mTORC1 and mTORC2. mTORC1 is known to receive inputs from multiple signaling pathways, including growth factors, nutrients, and cellular energy levels to stimulate protein synthesis by phosphorylating key translation regulators such as ribosomal S6 kinase (S6K) and eukaryote initiation factor 4E binding protein 1 (4EBP1). In contrast, mTORC2 regulates cell morphology and also phosphorylates AKT. Recent studies have established that dysregulated mTOR activity is associated with several hamartoma syndromes and metabolic disorders. The mechanism of mTOR regulation by numerous intracellular signaling pathways and the function of mTOR in physiological regulation will be discussed.