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The contribution of the different apical ectodermal ridge‐FGFs to limb development
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.234.2
Subject(s) - apical ectodermal ridge , limb development , zone of polarizing activity , limb bud , fibroblast growth factor , anatomy , fgf8 , biology , tetrapod (structure) , ridge , ectoderm , gene , genetics , embryogenesis , receptor , paleontology
Half a century ago the apical ectodermal ridge (AER) at the distal tip of the tetrapod limb bud was shown to produce signals necessary for limb development. Members of the FGF gene family are key AER‐derived signals, with Fgf4, Fgf8, Fgf9, and Fgf17 specifically expressed in the mouse AER. The results of genetic ablation experiments in the mouse designed to assess the contribution of the different AER‐FGFs to limb development will be discussed.