Premium
Oxidative damage to human cortex in aging an antioxidant use
Author(s) -
Sonnen Joshua Aaron,
Gray Shelly,
Larson Eric B.,
Montine Thomas Jude
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.167.2
Subject(s) - docosahexaenoic acid , dementia , oxidative stress , antioxidant , oxidative damage , oxidative phosphorylation , myelin , medicine , chemistry , biochemistry , fatty acid , central nervous system , polyunsaturated fatty acid , disease
Oxidative damage has been proposed as an underlying mechanism of the neurodegenerative processes in age‐related cognitive decline and dementia. Frozen parietal cortex from rapid autopsies from the Adult Changes in Thought study, a longitudinal, community‐based study of aging with extensive medication and clinical history and neuropathologic endpoints, was evaluated for absolute content of oxidative products of arachadonic acid (IsoP), docosahexaenoic acid (NeuroP) and adrenic acid (MyeloP) as surrogates for oxidative damage to plasma membranes, neuron cell membranes and myelin membranes respectively. Current smoking, but not obesity were associated with increased IsoP and NeuroP, but not MyeloP levels, and history of Vit C and E use failed to moderate this effect.