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Moderate hypoxia (10 kPa) extends lifespan with adult but not juvenile exposure in the fruitfly, Drosophila melanogaster
Author(s) -
Harrison Jon Fewell,
Rascon Brenda
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1239.33
Subject(s) - hyperoxia , juvenile , drosophila melanogaster , longevity , oxygen , hypoxia (environmental) , biology , life span , zoology , reactive oxygen species , ecology , chemistry , biochemistry , genetics , evolutionary biology , organic chemistry , gene
Oxygen provides the substrate for most ATP production but also serves as the source of reactive oxygen species that promote aging. Multiple invertebrate studies have shown that pure oxygen atmospheres strongly reduce life span, but it is unknown whether the relationship between oxygen level and life span is linear across varying atmospheric p O 2 levels. In this study, we reared Drosophila melanoga s ter at five adult oxygen levels (2, 10, 21, 40 or 100 p O 2 ) in order to investigate the relationship between atmospheric oxygen and life span. We show that that the response of fruit fly life span to ambient oxygen is parabolic, with, reduced longevity at higher and lower oxygen levels; the optimal p O 2 for longevity is moderately hypoxic (10 kPa). We also reared D. melanogaster at three juvenile p O 2 levels, to test whether juvenile exposure to hypoxia or hyperoxia leads to compensatory responses that enhance the ability of flies to cope with high or low oxygen as adults. In general, there was little evidence for beneficial plasticity, and most of the data suggested that exposure to hypoxia or hyperoxia as juveniles lead to damage that exacerbated effects of non‐optimal oxygen levels in adults. Supported by NSF IOB 0419704 to JFH and NSF HRD‐0114712 to WAESO at ASU.