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Effects of prenatal stress on cardiovascular regulation in offspring
Author(s) -
Hines Tina
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1228.1
Subject(s) - offspring , corticosterone , endocrinology , medicine , baroreflex , prenatal stress , pregnancy , hormone , heart rate , blood pressure , biology , genetics
Certain prenatal disorders increase risk for cardiovascular disease in adult offspring. We tested the effect of reduced uterine perfusion (RUP) during pregnancy on arterial pressure (AP), baroreflex and stress regulation in adult rat offspring. Uterine vessels were clipped (RUP) on gestational day 14. Resting AP, baroreflex control of heart rate (HR), and AP, HR and glucose and corticosterone (cort) responses to 60‐min. restraint stress were measured in conscious chronically instrumented offspring. Baroreflex control of renal sympathetic nerve activity (RSNA) was assessed in anesthetized offspring. Resting AP was ~10mmHg higher in RUP offspring from 8–12wks in males and 8–20 wks in females. Baroreflex control of HR and RSNA was similar in all groups of 8wk offspring. AP and HR at 10 and 60 min. of restraint were also similar among offspring groups. Glucose levels after 10 min. of restraint were lower in RUP male offspring, and plasma cort was lower after 60 min in this group compared with control male offspring. The cort response to stress peaked at a higher level in RUP female offspring at 10 min. and remained higher than control at 60 min (~140ug/dl). Resting AP is modestly increased in adult male and female RUP offspring. Baroreflex regulation of HR and RSNA does not appear to be adversely affected in these rats. Results suggest sex differences in metabolic and hormonal responses to stress in RUP offspring. NIH NR04184.