Premium
Pressure overload exacerbates insulin resistance in obesity and type 2 diabetes
Author(s) -
Marsh Susan A,
Dell’Italia Louis J,
Chatham John C
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1226.35
Subject(s) - insulin resistance , medicine , endocrinology , diabetes mellitus , insulin , type 2 diabetes , obesity , heart failure , blood pressure
Insulin resistance and type 2 diabetes are associated with a high fat diet, hypertension and obesity. Hypertensive diabetic patients have an increased risk for progressing to heart failure, a condition also associated with insulin resistance in non‐diabetics. Young male rats were divided into control (CON; 12% kcal fat/19% protein/69% carbohydrate), high fat diet (HF; 60/19/21%) and type 2 diabetic (DIA; high fat diet + low dose streptozotocin) groups and after 8 weeks underwent sham (SH) or pressure overload (PO) surgeries. Fasting glucose levels were elevated in DIA (10.8 ± 1.3 mmol/l) compared to CON (3.5 ± 0.1 mmol/l) and HF (3.9 ± 0.2 mmol/l); there were no differences between SH and PO. Mortality was higher in DIA‐PO (30%) and CON‐PO (25%) compared to HF‐PO (8%) and there was 100% survival in all SH groups. Four weeks after surgeries, insulin sensitivity was 20% lower in DIA‐PO compared to DIA‐SH and this difference widened to 42% after 8 weeks; at both time points, HF‐SH were more insulin resistant than CON‐SH. At 4 weeks insulin sensitivity in CON‐PO and HF‐PO was not different from their respective SH; however, at 8 weeks insulin sensitivity in HF‐PO was 35% lower than HF‐SH. These data suggest that insulin resistance and mortality are exacerbated by pressure overload in type 2 diabetic animals, which may contribute to increased heart failure and mortality in diabetic patients.