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The analysis of avian plasma for the glycation of serum albumin
Author(s) -
Anthony Claire M.,
Braun Eldon J.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1226.18
Subject(s) - glycation , albumin , diabetes mellitus , medicine , endocrinology , chemistry , in vivo , serum albumin , blood proteins , type 2 diabetes , biology , microbiology and biotechnology
Plasma glucose concentrations (Pglu) in humans are closely regulated at about 80–100mg%. If the Pglu levels reach 150mg% or greater for 4–6 weeks, the symptoms of Type 2 diabetes will begin to appear; peripheral vascular disease and/or retinal damage. These symptoms are the result of the glycation of serum albumin and a subsequent series of reactions that lead to formation of advanced glycation end‐products (AGEs). The AGEs bind to vascular tissues leading to pathologies that appear as symptoms of Type 2 diabetes. In contrast, to humans, the Pglu of birds ranges from 350–750mg%. The striking circumstance is that birds do not suffer the pathologies associated with Type 2 diabetes. In an attempt to gain an understanding of this discrepancy, we have begun experiments to analyze the interaction between glucose and the serum albumin of birds (experimental animal: Mourning doves). In particular, the analysis of this reaction under in vitro and in vivo conditions to determine the potential for avian albumin to become glycated and the amount of albumin normally occurring in one avian species.