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Blue light phase advances entrained rhythms of brain temperature and sleep in rhesus monkeys
Author(s) -
Robinson Edward L,
Fuller Charles A
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1222.4
Subject(s) - circadian rhythm , entrainment (biomusicology) , slow wave sleep , sleep (system call) , endocrinology , rhythm , free running sleep , medicine , biology , neuroscience , electroencephalography , suprachiasmatic nucleus , light effects on circadian rhythm , computer science , operating system
Blue light sensitive retinal ganglion cells and their neural projections appear to be the main pathway for the effects of light on circadian entrainment and alerting. The effects of blue light on rhythms and sleep in a 24 hour light‐dark cycle were studied in a rhesus monkey model. Six individually housed and unrestrained animals were entrained in cool‐white fluorescent light (WH) for 12 hours daily (LD 12:12), then exposed to 4 days of LD12:12 with blue LED lamps (BL). Both sources averaged 6.1 x 10 13 quanta cm −2 s −1 at eye level. Performance was measured using the Psychomotor Test System (Georgia State Univ.). Brain temperature (T br ) and sleep were recorded via biotelemetry. Sleep stages from the last two days of WH and BL were scored in 30‐second epochs. The average fraction of time in sleep over 24‐hours, as well as during L or D, did not differ between WH and BL. Shallow slow‐wave sleep (stages 1 and 2) and deep slow‐wave sleep (stages 3 and 4) also showed no significant differences. The fraction of time in REM sleep over 24‐h was significantly elevated as was REM during D. Acrophases from sine fits showed a statistically significant advance of the phase angle of entrainment in T br , in the first two days of BL. Acrophases and average waveforms of sleep stages from the subsequent two days show apparent phase advances and a slight increase in daytime sleep, but did not differ significantly. (Supported by NASA Grant NNJ04HF44G)