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Prediabetes in the absence of the metabolic syndrome is associated with impaired brachial artery flow‐mediated dilation
Author(s) -
Eskurza Iratxe,
Fay Tara N.,
Walker Ashley E.,
Seals Douglas R.,
Pierce Gary L.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1211.8
Subject(s) - prediabetes , medicine , brachial artery , waist , cardiology , endothelium , endocrinology , endothelial dysfunction , diabetes mellitus , blood pressure , obesity , type 2 diabetes
Endothelium‐dependent dilation (EDD) is impaired with aging, but there is marked variability in EDD among older adults. The prevalence of prediabetes (Pre‐DB) increases with age, but it is unknown if Pre‐DB influences age‐associated reductions in EDD, particularly in the absence of other major cardiovascular disease risk factors. To determine this, brachial artery flow‐mediated dilation (FMD) was measured in 34 young (YN, age=23±1 yr, mean±SE) and 14 older (ON age=65±1 yr) healthy men with normal fasting blood glucose (FBG<99 mg/dl), and in 10 healthy older men with impaired FBG (FBG>100 mg/dl) (OPre‐DB, age=68±1 yr). FBG was similar in YN and ON (87.1±1.2 vs. 88.9±1.7 mg/dl, p>0.05), but higher in Opre‐DB (104.6±2.1 mg/dl, p<0.05). Brachial FMD was 30% lower in ON vs. YN (5.3±0.7 vs. 7.8±0.3 %, p<0.05). Most importantly, FMD was 43% lower in OPre‐DB (3.1±0.5 %) vs. ON and 60% lower in OPre‐DB vs. YN (p<0.05). Endothelium‐independent dilation did not differ among groups (p=0.86). The difference in FMD between OPre‐DB and ON was reduced by ∼half (3.9±0.7 vs. 5.0±0.7%) and was no longer statistically significant after correcting for waist‐to‐hip ratio (p>0.05). These results support the hypothesis that prediabetes, in the absence of the metabolic syndrome, modulates the age‐associated reduction in EDD, in part via increased abdominal fat. Supported by NIH AG013038, AG022241, AG006537, AG000279.