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Insulin resistance, secretion and breakdown are increased 6 months following severe burn injury
Author(s) -
Cree Melanie G,
Fram Ricki Y,
Barr David,
Chinkes David,
Wolfe Robert R,
Herndon David N
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1205.2
Subject(s) - insulin resistance , medicine , insulin , burn injury , endocrinology , area under the curve , carbohydrate metabolism , glucose tolerance test , surgery
Insulin resistance following acute burns is well described, however, it is unknown how long this condition persists. Our objective was to measure the duration of insulin resistance following recovery from the acute burn injury. We performed a prospective cross‐sectional study with a 2 hr oral glucose tolerance test in 46 severely burned children at 6, 9 or 12 months (mo) following injury. Glucose uptake and insulin secretion were assessed, and compared to those previously published in healthy children. At 6 mo post‐burn, the 2 hr glucose was (P<0.001) greater than controls, and the area under the curve (AUC) of glucose was higher compared to 12 mo and to healthy children (P=0.027 and P<0.001, respectively). The 9 mo AUC glucose was higher than controls (P<0.01). The 6 mo 2 hour insulin in was higher than controls, as was the AUC of insulin in all time points post‐burn. The AUC of C‐peptide was greater at 6 mo post‐injury compared to 9 and 12 mo (P<0.01 for both). In conclusion, increased 2 hr and AUC glucose and insulin indicate that glucose metabolism is still altered at 6 and 9 mo post‐injury, coinciding with previously documented defects in bone and muscle metabolism at these times.