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Hormonal Regulators of Muscle and Metabolism in Aging (HORMA) study: body composition and performance outcomes
Author(s) -
Schroeder E Todd,
CastanedaSceppa Carmen,
Binder Ellen,
Wang Ying,
Kawakubo Miwa,
Yarasheski Kevin,
Bhasin Shalender,
Azen Stanley P,
Sattler Fred R
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1188.4
Subject(s) - sarcopenia , endocrinology , medicine , placebo , testosterone (patch) , lean body mass , skeletal muscle , hormone , trunk , composition (language) , anabolism , biology , body weight , ecology , linguistics , philosophy , alternative medicine , pathology
We hypothesized that endogenous testosterone (T) and growth hormone (GH), regulate skeletal muscle and fat by different but complementary mechanisms and augmentation to youthful levels would enhance body composition and function in older, community dwelling men at risk for sarcopenia/frailty. HORMA is a placebo controlled, double‐blind, factorial study to assess T & GH dose levels in hyposomatotropic (IGF‐1 in lower tertile), low/hypogonadal (T 200–500 ng/dL) 65–90 yr old men for 16wks. 122 subjects were randomized to 6‐groups, transdermal T (5 or 10g/day) and rhGH (0, 3, or 5μg/kg/day). Table shows the primary results. In addition, appendicular lean, trunk fat, aerobic endurance time significantly improved (p<0.05) but muscle power, fatigability, VO2peak did not. T alone or with GH improved body composition and select measures of muscle function.