Premium
Cardiovascular improvements after lung transplantation in patients with cystic fibrosis
Author(s) -
Layton Aimee M,
Rebmann Rebecca A,
De Meersman Ronald E,
Wilt Jessie S,
Bartels Matthew N
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1175.14
Subject(s) - medicine , cystic fibrosis , body mass index , cardiology , lung , lung transplantation , cycle ergometer , respiratory system , transplantation , ventilation (architecture) , pulmonary function testing , surgery , heart rate , mechanical engineering , blood pressure , engineering
Due to a lack of published data, we investigated the effects of lung transplantation on cardiopulmonary parameters for patients with cystic fibrosis (CF). METHOD: Pre‐ and post‐lung transplantation data from a traditional progressive cycle ergometer cardiopulmonary exercise test were retrospectively analyzed for 5 males and 5 females with cystic fibrosis. Most recent exercise tests were used for post‐transplant data, unless rejection was suspected at time of test. Last test prior to suspected rejection was used for these patients. RESULTS: Post‐transplant, patients showed significant improvements (p<0.05) at rest in heart rate (HR), respiratory rate (RR), minute ventilation (VE), energy expenditure per kilogram (REE), and body mass index (BMI). Oxygen consumption per workload was significantly decreased during peak exercise post‐transplant. CONCLUSION: Patients with CF who undergo lung transplant show improved cardiopulmonary function. The observed decrease in REE may have resulted from improved respiratory efficiency as shown by the decreased HR, RR, and VE at rest, and may contribute to nutritional status improvement as evidenced by increased BMI. Supported by VIDDA foundation.