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Erythropoietin (EPO) and Soluble Traansferrin Receptor (sTfR) Responses at 4300 m Before and After Normobaric Intermittent Hypoxic Exposure
Author(s) -
Staab Janet E.,
Muza S. R.,
Beidleman B. A.,
Fulco C. S.,
Staab J. S.,
Jones J. E.,
Reese M. L.,
Cymerman A.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1173.11
Subject(s) - medicine , erythropoietin , pulse oximetry , altitude (triangle) , endocrinology , anesthesia , geometry , mathematics
During continuous altitude exposure EPO initially rises then falls while sTfR rises progressively. The purpose of this study was to determine if one week of daily 3‐h normobaric intermittent hypoxic exposures (IHE) (2h PIO 2 =90mmHg rest, 1 h PIO 2 =110 mmHg exercise) would elicit the same EPO and sTfR responses observed during continuous altitude exposure. Fifteen sea‐level (SL) resident men (mean±SD;21±6 yr) were exposed to 4300 m in a hypobaric chamber (preIHE) followed by ~12 days at SL. Then, for 6–7 d, nine received IHE treatment (T‐IHE) and six received a sham IHE treatment (S‐IHE) followed by 2.5 d of no IHE before the 2nd 4300 m exposure (postIHE). Resting SaO 2 was measured during IHE by pulse oximetry. Serum EPO and sTfR (ELISA) were measured at SL and 24 h into each 4300 m exposure. Over ~7 d of IHE, SaO 2 during T‐IHE increased (p<0.01) from 75±4% to 81±5% while SaO 2 during S‐IHE remained at 98±1%. EPO (mIU/ml) increased (p<0.01) similarly for T‐IHE and S‐IHE from SL (8±1 vs. 6±1) to 4300 m during both PreIHE (143±38 vs. 146±46) and PostIHE (132±33 vs. 120±41). There was no change in EPO from PreIHE to PostIHE. sTfR (nmol/L) did not change for T‐IHE or S‐IHE from SL (17±1 vs. 18±1) to PreIHE (18±1 vs. 20±1) or PostIHE (18±1 vs. 18±1). Thus, 6–7 d of IHE did not elicit similar responses in EPO and sTfr as observed during continuous altitude exposure. Funding provided by USAMRMC. Authors’ views; not official U.S. Army or DoD policy.