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Exercise training improves central NMDA‐induced erectile dysfunction in diabetes
Author(s) -
Zheng Hong,
Liu Xuefei,
Patel Kaushik
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1170.1
Subject(s) - erectile dysfunction , medicine , diabetes mellitus , microinjection , sodium nitroprusside , endocrinology , nitric oxide
Erectile dysfunction is a serious and common complication of diabetes mellitus. Apart from the peripheral actions, central mechanisms are also responsible for the penile erection. The goal of the present study was to determine the impact of exercise training (ExT) on the central NMDA‐induced erectile dysfunction in streptozotocin (STZ)‐induced diabetic rats (Type 1 diabetes‐T1D). In rats with T1D, ExT (treadmill run for 3 weeks) significantly improved the blunted erectile response to NMDA (50ng) microinjection within the paraventricular nucleus (PVN) (T1D+ExT 3.0±0.6 penile erection/rat; T1D 0.5±0.3 penile erection/rat within 20mins). Consistent with the erectile response, other behavior responses including yawning, stretching, chewing and grooming induced by central NMDA microinjection were significantly increased in T1D rats after ExT. Furthermore, ExT also improved erectile dysfunction induced by central administration of exogenous nitric oxide (NO) donor, sodium nitroprusside (SNP) in T1D rats. These results suggest that ExT may have beneficial effects on the erectile dysfunction in diabetes through improvement of central NO bioavailability within the PVN.