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Elevated serum advanced glycation end products and poor grip strength in older community‐dwelling women
Author(s) -
Dalal Mansi Sunil,
Ferrucci Luigi,
Sun Kai,
Fried Linda,
Varadhan Ravi,
Walston Jermey,
Guralnik Jack,
Semba Richard
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1163.6
Subject(s) - medicine , grip strength , glycation , quartile , hand strength , diabetes mellitus , advanced glycation end product , weakness , endocrinology , sarcopenia , etiology , body mass index , rage (emotion) , physical therapy , surgery , psychology , confidence interval , neuroscience
Background: Aging is characterized by loss of muscle strength, but its etiology is not well understood. Advanced glycation end products (AGEs) are bioactive compounds that are implicated in the pathogenesis of diabetes, cardiovascular disease, and renal failure. However, their relationship with skeletal muscle has not been well characterized. Objective: The objective of the study was to examine the relationship between serum AGEs, circulating receptor for AGEs (sRAGE), endogenous secretory RAGE (esRAGE), and grip strength in older women. Methods: Serum AGEs, sRAGE, esRAGE, and grip strength were measured in 559 women, age ≥65 years, in the Women's Health and Aging Study I. Results: The mean (SD) grip strength among women in the highest quartile of serum AGEs compared with the lower three quartiles was 18.2 (6.4) and 20.1 (6.2) kg, respectively ( P = 0.004). Women in the highest quartile of serum AGEs had decreased grip strength (beta = −1.31, SE = 0.61, P = 0.03) in a multivariate linear regression model, adjusting for age, race, BMI, cognitive dysfunction, and depression. Serum sRAGE and esRAGE were not significantly associated with grip strength. Conclusion: Women with high serum AGEs have greater muscle weakness. Further studies are needed to determine whether AGEs, a potentially modifiable risk factor, are associated with physical performance and disability in older adults.