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Premium Fetal programming increases susceptibility to renal injury induced by ischemia‐reperfusion in IUGR offspring
Author(s)
Ojeda Norma Beatriz
Publication year2008
Publication title
the faseb journal
Resource typeJournals
PublisherFederation of American Societies for Experimental Biology
Renal injury due to ischemia‐reperfusion (I‐R) is the major cause of acute renal failure. Whether susceptibility to renal injury from I‐R can be programmed during fetal life is unknown. Our laboratory has developed a unique rat model of placental insufficiency that results in intrauterine growth restriction (IUGR) and development of hypertension in IUGR rats. We hypothesized that IUGR will also lead to greater susceptibility to renal injury following I‐R. Physiological parameters were determined 1 week after mild renal ischemia (15 min); early histological renal changes were assessed in a subset of rats after 30 min of reperfusion. Mean arterial pressure (MAP), renal vascular resistance (RVR), and histological markers of renal damage were increased; glomerular filtration rate (GFR) and renal blood flow (RBF) were decreased following I‐R in IUGR compared to control (Table). Therefore, these findings suggest that influences during fetal life can program an increased susceptibility to renal injury suggesting IUGR individuals may be an ‘at risk’ population for renal disease.
Subject(s)biology , blood pressure , cardiology , endocrinology , environmental health , fetus , genetics , intrauterine growth restriction , ischemia , medicine , offspring , population , pregnancy , renal blood flow , renal function , renal injury , renal ischemia , reperfusion injury , urology
Language(s)English
SCImago Journal Rank1.709
H-Index277
eISSN1530-6860
pISSN0892-6638
DOI10.1096/fasebj.22.1_supplement.1159.11

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