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Wave intensity analysis of coronary pressure and velocity for studying coronary‐ventricular interactions
Author(s) -
Siebes Maria,
Kolyva Christina,
Verhoeff BartJan,
Wijngaard Jeroen P.H.M.,
Piek Jan J.,
Spaan Jos A.E.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1152.14
Subject(s) - cardiology , medicine , cardiac cycle , systole , contraction (grammar) , reactive hyperemia , vasodilation , blood pressure , diastole
Coronary wave intensity (WI) represents the energy carried by traveling waves that are generated by cardiac contraction and relaxation. Distal coronary pressure (Pd) and Doppler velocity (v) were measured in 26 patients at rest and during adenosine‐induced hyperemia before and after revascularization by stent placement. WI was calculated as (dPd/dt) x (dv/dt) and separated into forward (FW) and backward (BW) components during the cardiac cycle. We found a consistent pattern of BW and FW compression waves during ventricular contraction followed by FW and BW expansion waves in the early ventricular relaxation phase. Individual energies of expansion and compression waves traveling in the same direction were strongly correlated (P< 0.001). The size of BW compression and expansion waves was similar, while FW compression waves were in all cases larger than FW expansion waves (P<0.01). The energy of BW waves at rest was strongly correlated with that during hyperemia (P<0.001). An increase in BW wave energy after stent placement was strongly related to an increase in coronary microvascular conductance (P<0.001). Our results are consistent with the intramyocardial pump model (BW waves), higher wall stiffness at the end of systole (difference in FW waves) and similar redistribution of vascular resistance at vasodilation (rest vs hyperemia) despite different vascular anatomy. (Support: NHF grants 2000.090 and 2006B186)