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Occlusive, diffuse coronary artery disease in Ossabaw miniature swine with metabolic syndrome
Author(s) -
Neeb Zachary Paul,
Edwards Jason M,
Bratz Ian N,
Alloosh Mouhamad A,
Schultz Carrie,
Thompson Kristi,
Cunha Timothy,
Sturek Michael
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1152.10
Subject(s) - medicine , coronary artery disease , metabolic syndrome , miniature swine , dyslipidemia , endocrinology , cholesterol , cardiology , obesity
Coronary artery disease (CAD) is increased in patients with metabolic syndrome (MetS), which is a cluster of risk factors. Ossabaw miniature swine replicate all features of MetS when fed excess kcal atherogenic diet high in trans fat/cholesterol/fructose. We hypothesized that Ossabaw swine fed mixed fatty acid atherogenic diet will exhibit more severe MetS and CAD. Lean pigs (N=9) were compared to pigs that developed MetS after 22 weeks of high cholesterol/fructose diet with trans fat (TMetS; N=8) or mixed fat (hydrogenated oil, coconut oil, lard) (MMetS; N=6). Triglycerides, LDL cholesterol, and LDL/HDL ratio in MMetS (85 ± 20; 284 ± 37 mg/dL; 5.2 ± 0.9, respectively) were profoundly increased vs. TMetS (39 ± 2; 130 ± 28 mg/dL; 2.0 ± 0.3, respectively) and lean (23 ± 4; 14 ± 3 mg/dL; 0.3 ± 0.1, respectively). MMetS and TMetS were hypertensive, but MMetS was more insulin resistant vs. TMetS and lean. Lean had virtually no CAD. TMetS CAD was mostly fatty streaks in proximal segments. Strikingly, MMetS CAD was occlusive (44% stenosis), diffuse (59% wall coverage in distal segments), and complex, including calcification. CONCLUSION: Ossabaw swine that develop MetS on mixed fat atherogenic diet have profound dyslipidemia and CAD. Support: RR013223 , HL062552 , Purina TestDiet.