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The cerebral metabolic ratio during exercise in patients with cirrhosis
Author(s) -
Gam Christiane,
Rasmussen Peter,
Seifert Thomas,
Secher Niels H,
Larsen Fin S,
Nielsen Henning Bay
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1151.29
Subject(s) - medicine , cirrhosis , endocrinology , anaerobic exercise , propranolol , carbohydrate metabolism , physical therapy
Intense exercise decreases the cerebral metabolic ratio of O 2 to carbohydrates (glucose + (1/2)lactate). It is not known whether these variables are influenced by exercise in patients with cirrhosis and seven cirrhotic patients (five treated with propranolol) underwent ergometer cycling to exhaustion. Arterial lactate increased to 5.0 ± 0.3 mM (mean ± SEM; P < 0.05) and arterial‐jugular venous (a‐v) difference from −0.01 ± 0.03 mM at rest to 0.30 ± 0.05 mM (P < 0.05). Arterial glucose was 7.0 ± 0.6 mM and its a‐v difference 0.64 ± 0.07 mM was not different from that at rest (0.54 ± 0.03 mM). In healthy subjects maximal exercise increased arterial lactate to 12.9 ± 1.2 mM, and the a‐v lactate and a‐v glucose difference were 1.46 ± 0.25 and 0.79 ± 0.10 mM, respectively (P < 0.05). While the cerebral metabolic ratio decreased from 5.5 ± 0.5 at rest to 3.8 ± 0.3 (P < 0.05) during exercise in healthy subjects when arterial lactate was ≈5 mM, the cerebral metabolic ratio was not changed exercise in patients with cirrhosis. During exercise in patients with cirrhosis, the cerebral metabolic ratio is not affected, as the cerebral extraction of glucose and lactate are lowered and fatigue does not relate to a reduction in the cerebral metabolic ratio. A beta1+2‐receptor antagonist may influence the cerebral substrate uptake during exercise.