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Cerebrovascular Autoregulation is Lost with Diabetes Progression
Author(s) -
Elgebaly Mostafa Mahmoud,
Mezzetti Erin,
Sachidanandam Kamakshi,
Dorrance Anne,
Ergul Adviye
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1151.13
Subject(s) - diabetes mellitus , medicine , autoregulation , cardiology , tone (literature) , vascular disease , lumen (anatomy) , myogenic contraction , endocrinology , blood pressure , smooth muscle , art , literature
Cerebrovascular tone is critical in autoregulation of flow. Previously, we have shown remodeling of cerebrovasculature in diabetes and when ischemia / reperfusion injury was added, there was interestingly reduced infarct, yet increased hemorrhage. Hence the hypothesis behind the current study was that diabetes causes cerebrovascular remodeling leading to increased vascular tone. Aims were: to examine both the effects of diabetes and its progression on myogenic tone, vascular structure and mechanics. Pressurized middle cerebral arteries from 10 and 18 week‐old Wistar and diabetic Goto‐Kakizaki (GK) rats using the arteriograph showed that: GKs lost their myogenic tone with diabetes progression (18±3 vs. 5±3, p<0.023). At 10 weeks there was no significant remodeling. At 18 weeks GK rats had higher media: lumen ratio (0.179 ± 0.04 vs. 0.075± 0.01, p<0.0001) and lower tone (5±3 vs. 20±5, p<0.0004) compared to control. Cerebrovascular changes starts early with diabetes and worsens with disease progression thus vascular dysfunction ensues via altered mechanics and structure. This may account in part for worse hemorrhage in diabetes.