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Species differences in collaterals arising from femoral artery occlusion: a comparison from mice to men
Author(s) -
Distasi Matthew R,
Ziegler Matthew A,
Case Jamie,
Miller Steven J,
Murphy Michael P,
Dalsing Michael C,
Sturek Michael,
Unthank Joseph L
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1147.4
Subject(s) - vasa vasorum , internal elastic lamina , arteriogenesis , occlusion , collateral circulation , anatomy , femoral artery , artery , medicine , arteriole , cardiology , hemodynamics , biology , ischemia , circulatory system
Animal studies of therapies to enhance vascular compensation to arterial occlusion have failed to predict clinical outcomes, indicating the need for improved models. Collateral arteries resulting from femoral artery occlusion were compared between humans, mice, rats, and pigs. Collateral location and size was determined from angiograms and vascular casts. Wall morphology was assessed from cross‐sections in all species except human. The primary collaterals orginated and re‐inserted in non‐ischemic upper leg tissues. Dramatic intimal cell proliferation/recruitment occurred; the internal elastic lamina remained intact without evidence of neo‐intimal formation. Collateral size ranged from ∼0.1 mm in mice to >1 mm in larger species. A vasa vasorum was not observed in mouse collaterals and was much more extensive in pig than rat collaterals. A 10–100‐fold difference was observed between species in vascular wall thickness, ratio of endothelial to smooth muscle cells, and distance from ischemic tissue. These differences would be expected to impact the balance between growth modulators and reactive species and their paracrine effects due to diffusion distances. In addition, it is unknown how differences in hemodynamics and the presence of a vaso vasorum may impact collateral growth. Studies are warranted in larger species which may more closely mimic human collaterals. Support: HL42898, RR013223 , HL062552.