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A fermented Cordyceps sinensis product Cordymax‐6 improves sexual functions via PDE‐5 Inhibition and central pathways
Author(s) -
Gao Ling,
Zhang Yan,
Zhao Chunsheng,
Yang Jieying,
Zhou Yanjiao,
Tan Ningzhi,
Zhu JiaShi
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1137.15
Subject(s) - cordyceps , biology , pharmacology , medicine , endocrinology , botany
Cordyceps sinensis (Cs) is an anti‐aging medicinal herb with profound therapeutic activities in enhancing endurance and sexual functions (JACM 4:289, and 4:429, 1998). Sexual enhancement activities of CordyMax (CM), a Cs replacement fermented with Paecilomyces hepiali, were proven in humans (CTPM 9:29, 1988). We reported the activities of CM in anti‐fatigue and glucose‐lipid metabolisms. We now investigated CM6 on the improvement of sexual functions in vivo. Male Wistar rats were given CM6 (0.32, 0.8 or 2.0g/kg) or a control Viagra (0.05g/kg) by gavage. Platelets were isolated after animals received 3 doses of treatment. PDE‐5 activity was assayed, showing 23% to 40% inhibitions by CM6 therapy (p<0.01). In the 2nd experiment after received 3 doses of CM6 (0.6, 1.2 or 1.8g/kg), male KM mice in CM6/1.8g/kg group showed shortened mounting latency (p<0.01). In the 3rd experiment, Orchiectomized SD rats were given CM6 (0.6, 1.2 or 1.8g/kg) by gavage. Erection latency (EL) was assessed on Days 3 & 22. CM6 shortened EL in orchiectomized rats in a dose‐dependent manner. Compared to controls, rats in CM6/1.8g/kg group showed decreased EL (p=0.048). Our data indicate sexual enhancement activities of CM6, possibly through PDE‐5 inhibition and central pathways.