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The Effect of PEGylated Fibrin Injection On The Recovery Of Skeletal Muscle Function Following Ischemia‐Reperfusion Injury.
Author(s) -
Gokhale Rohit,
Fegan Kelly,
Suggs Laura,
Farrar Roger
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1137.12
Subject(s) - fibrin , skeletal muscle , ischemia , regeneration (biology) , muscle tissue , in vivo , medicine , biomedical engineering , chemistry , anatomy , microbiology and biotechnology , biology , immunology
Ischemia/Reperfusion (I/R) injury can cause irreversible damage to muscle tissue. PEGylated Fibrin is an inert substance which can be used to deliver growth factors to improve regeneration in such irreversibly damaged muscle. In this study we evaluated the effect of PEGylated Fibrin injection on the recovery of skeletal muscles following the application of 4‐hour pneumatic tourniquets. There was no significant difference in force recovery between injection and non‐injection groups for the In Vivo force assessment (p=0.19), the In Situ force assessment (p=0.12) and the Specific tetanic tension of the muscle tissue (p=0.51). Histological assessment of the muscles did not reveal any significant differences between the injected and non‐injected muscle. While fibrin injection is known to induce an inflammatory response, it did not appear to affect recovery of function in these muscles. These results indicate that PEGylated fibrin gel has no detrimental effect on muscle tissue when injected, making it an appropriate material to deliver growth factors into skeletal muscle. This work was funded in part by the U.S. Army Medical Research and Material Command grant DAMD W81XWH‐06‐1‐0540 to RPF.