Premium
Herb‐drug interaction involving oseltamivir and Chinese medicine formula
Author(s) -
Chow Moses Sing Sum,
Chang Qi,
Zuo Joan
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1136.24
Subject(s) - cmax , pharmacology , pharmacokinetics , metabolite , drug , active metabolite , medicine , chemistry , urine , drug interaction
Aim: The empiric use of certain Chinese medicine formula (CMF) in combination with oseltamivir (O) is advocated for the treatment of deadly avian influenza in Asia. This study aimed to determine the interaction potential of such combination. Method: Two groups of rats received either O alone or O+CMF (Yin Qiao San/Sang Ju Yin) at equivalent human doses for 5 days. CMF was given 2 h post O dose. Following the last dose, urine as well as plasma O and its active metabolite (M) concentrations were determined, after adding dichlorvos to prevent hydrolysis of O. All drug concentrations were determined by a validated LC/MS/MS method. Result: The Cmax and area under the concentration time curve of M were significantly reduced in the combination compared to O alone group (1.3±0.2 vs 1.8±0.3 ug/ml and 326±30 vs 452±101 ug.min/ml respectively, P <0.05). The M/ O ratios were 1.96±0.25 vs 2.92± 0.69 respectively (P<0.05). A trend of greater renal clearance of M in the combination group (7.60 vs 6.24 ml/min) was also observed. Conclusion: Our results indicate that CMF can potentially cause a significant reduction of the active M concentration, most likely due to suppression of O metabolism as well as possibly enhanced M renal clearance. Pharmacokinetic interactions from herb‐drug combinations could potentially involve multiple mechanisms and should be carefully studied before their empiric use. (Funded by Hospital Authority of Hong Kong).