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Neurogenesis from Neuroglia: Curcumin's potential role in transforming neuroglia into neurons
Author(s) -
Gouw Arvin,
Panchal Heena,
Ho Jacqueline,
Ghazi Kamelia,
Chang Tinny,
Singh Satbir,
Timiras Paola S.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1125.5
Subject(s) - nestin , curcumin , neurogenesis , neuroglia , glial fibrillary acidic protein , astrocyte , transdifferentiation , gfap stain , biology , astrogliosis , glioma , oligodendrocyte , neurosphere , microbiology and biotechnology , gliosis , cellular differentiation , neuroscience , stem cell , cancer research , neural stem cell , immunology , myelin , immunohistochemistry , biochemistry , central nervous system , adult stem cell , gene
The anti‐oxidative, anti‐inflammatory and anti‐proliferative actions of Curcumin, the active ingredient in turmeric are well known. Previous studies on Rat C6 Glioma cells show that curcumin stimulates neuroglial cell maturation and differentiation. Neuroglial cells, astrocytes, and oligodendrocytes are closely related to neurons developmentally, and support neuronal function. DNA microarrays reveal that neurofilament M, involved in neurogenesis, is upregulated by curcumin in cultured neuroglioma. These studies investigate curcumin's possible role in transdifferentiation of these cells into precursor cells. Cultured Rat C6 Glioma cells were cultured with 1μM and 5 μM curcumin for 2 and 7 days. They were then stained for glial fibrillary acid proteins (GFAP), a neuroglial marker, and with Nestin, a neuronal marker, at the end of each trial. Our immunofluorescent images showed loss of GFAP neuroglial expression and a progressive increase in expresssion of Nestin in cells treated with curcumin for 7 days. Thus curcumin may also play a role in neurogenesis from neuroglia. Supported by NIH Grant AG 19145‐05.