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The 5‐HT 7 Dro Serotonin Receptor: Expression in the CNS and Function
Author(s) -
Becnel Jaime T,
Johnson Oralee,
Nichols Charles D.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1125.2
Subject(s) - 5 ht receptor , biology , serotonin , endocrinology , medicine , receptor , circadian rhythm , neuroscience , genetics
Serotonin (5‐HT) influences behaviors that include circadian, sleep, appetite, aggression, locomotion, perception, and sexual behavior. The effects of 5‐HT are mediated through G‐protein coupled receptors, which initiate multiple effector pathways. Disregulation of 5‐HT signaling in humans has been implicated in neuropsychiatric disorders including depression, anxiety disorders, anorexia and schizophrenia. The fruit fly, Drosophila melanogaster, expresses orthologs of three mammalian 5‐HT receptor subtypes: 5‐HT 1A , 5‐HT 2 , and 5‐HT 7 . The 5‐HT 7 Dro receptor is orthologous to the mammalian 5‐HT 7 receptor and activates adenylate cyclase through G αs . We show that in fly 3rd instar larvae brain, 5‐HT 7 Dro expression is observed in discreet populations of neurons in the hemispheres as well as in neurons of the ventral ganglia. In adult brains, 5‐HT 7 Dro is highly expressed in neurons that innervate the ellipsoid body, a region believed to be involved in higher order behaviors. 5‐HT 7 Dro neurons also cluster with PDF‐positive circadian pacemaker neurons. Pharmacological studies using the 5‐HT 1A/7 receptor agonist 8‐OH‐DPAT with the 5‐HT 1A receptor antagonist WAY100635 eliminated circadian activity. These results suggest that 5‐HT 7 Dro may modulate circadian activity in the fly. Further studies to determine the role of 5‐HT 7 Dro in additional behaviors are ongoing. Supported by NIMH 1R21MH078454