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Genetic variations of the carbonic anhydrase gene were associated with hepatocellular carcinoma in Korean population
Author(s) -
Lee Seung Ku,
Yi CheongHo,
Kim MinHo,
Cheong Jae Youn,
Cho Sung Won,
Kang Jason Jongho,
Yang SongJu,
Kwack KyuBum
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1124.12
Subject(s) - hepatocellular carcinoma , haplotype , single nucleotide polymorphism , gene , cirrhosis , carbonic anhydrase , biology , genetics , liver cancer , population , genetic association , cancer research , medicine , genotype , enzyme , biochemistry , environmental health
Carbonic anhydrase (CA) gene family has been identified at least 15 different isoforms in mammalian. Previous studies have shown that its expression is induced in the endothelium of neovessels in cancer. Altered CA genes expression was associated with hepatocellular carcinoma (HCC). Genetic variations can be analysed to assess the risk of an individual for a particular diseases. To genetic association test, we investigated that CA genes contains variants are associated with chronic liver diseases including chronic hepatitis (CH), liver cirrhosis, and HCC, we genotyped CAs SNPs markers on 117 patients with CH, 112 HCC and 117 spontaneous recovery (SR) controls. In this study, we found that CA genes SNPs, haplotypes, and diplotypes were associated with HCC. The results of the present study suggest that CA genes SNPs and haplotype might be associated with the susceptibility of HCC.