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Bowel Mucosa Lymphoid Tissue in Experimental DMH Administration
Author(s) -
Cabrita Antonio Silverio,
Farinha Rodrigo,
Rafael Ana Isabel,
MatosBeja Manuel Correia
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1120.5
Subject(s) - lamina propria , lymphatic system , intestinal mucosa , medicine , pathology , large intestine , lymphatic tissues , oral mucosa , histology , mucosa associated lymphoid tissue , muscularis mucosae , gastroenterology , epithelium , malt lymphoma
The colon lamina propria is rich in lymphatic noduli (LN), which can occasionally become more proeminent in the mucosa. This can be caused by numerous stimuli. This work reports the changes found in the lymphoid tissue nodulae at the bowel mucosa level. We used 60 Wistar male rats randomly distributed in three groups of twenty animals each: group I, kept with no manipulation; group II submitted to the administration of 15mg DMH/Kg twice a week during 8 weeks, after which were sacrificed; group III submitted to the administration of the same toxic and concentration, for 8 weeks, sacrificed 4 weeks after the last administration. The intestine was collected for histology. By morphometry we evaluated the percentage of each lymphatic nodule that is present in the mucosa area. In the control group we didn't find LN occuping the mucosa area. In group II the LN area, for a 95% confidence interval varies between 211.1 and 234.7, and the percentage of LN area in the mucosa varies between 28.9% and 30.2%. The presence of LNs in the mucosa was 15% of the animals. In group III the LN area, for a 95% confidence interval varies between 236.1 and 290.1, and the percentage of LN area in the mucosa varies between varies between 24.7% and 28.8%. The presence of LNs in the mucosa was 35% of the animals. According to these findings, this carcinogen increased the bowel lymphoid tissue present in the mucosa.