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No change in endothelium‐dependent relaxation or morphology of peripheral arteries following 30 days of aortic coarctation.
Author(s) -
Newcomer Sean,
Hsu Charlie,
Caron Normand,
Ingram David,
Roseguini Bruno,
Laughlin Harold
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1119.8
Subject(s) - vasodilation , endothelium , peripheral , medicine , blood pressure , cardiology , endothelial dysfunction , brachial artery , aorta , anatomy , endocrinology
We designed this study to evaluate the effects of thoracic aortic coarctation (AC) on peripheral endothelial function and development of atherosclerosis. Endothelial function and development of atherosclerosis were assessed in the brachial (BR) and femoral (FEM) arteries of control (CON; n=6) and coarctated (COA; n=7) swine 30 days after AC. In vitro assessments of vasorelaxation to increasing doses of endothelium‐dependent and –independent vasodilators were performed in arterial rings harvested from the BR and FEM arteries. Intimal medial thickness (IMT) and sudan IV staining were performed in the BR and FEM arteries. AC produced a 30 day average blood pressure gradient of 56 ± 5mmHg across the coarctation. Elevated blood pressure proximal to the coarctation produced a significantly greater heart to body weight ratio in the COA (5.51 ± 0.06g/kg) vs. CON (4.66 ± 0.15g/kg) swine. Endothelium‐dependent and ‐independent relaxation was not significantly different in the BR or FEM arteries of COA and CON swine. In addition, there were no significant differences in either IMT or sudan IV staining of the BR or FEM arteries from COA and CON swine. These findings suggest that the stimulus and/or duration of 30 days AC were insufficient to produce endothelial dysfunction and atherosclerosis in the peripheral vasculatures of these swine. Supported by NIH HL083597 , HL36088 and HL52490