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Effects of endurance exercise training on endothelial function and atherosclerosis in the hereditary hypercholesterolemic swine model
Author(s) -
Newcomer Sean,
Roseguini Bruno,
Esquivel Arturo Arce,
Bender Shawn,
Turk James,
Laughlin Harold
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1119.6
Subject(s) - medicine , coronary arteries , endurance training , aorta , cardiology , thoracic aorta , endothelium , treadmill , coronary atherosclerosis , endocrinology , artery , coronary artery disease
Hereditary hypercholesterolemic (HH) swine develop advanced atherosclerotic lesions throughout the coronary and peripheral vasculatures. The purpose of this study was to test the hypothesis that endurance exercise training would increase endothelial function and decrease the prevalence of atherosclerosis in this swine model. Ten adult pigs were randomly assigned into either exercise trained (EX) or sedentary groups (SED). Exercise training consisted of 16 weeks of treadmill running. Upon sacrifice the following arteries were harvested: thoracic aorta (TA), carotid (CA), brachial (BR), femoral (FEM) and coronary arteries (LAD, RCA, CFX). In vitro assessment of endothelium‐dependent dilation (EDD) was determined by administering increasing doses of acetylcholine to BR and FEM rings and bradykinin to CFX rings. Atherosclerotic lesion formation was quantified through Sudan IV staining in the TA, CA, BR, FEM, LAD and RCA. Endurance exercise training increased EDD in the BR and FEM but not in the CFX. The percentage of Sudan IV staining was not significantly different between EX and SED swine in the TA, CA, BR, FEM, RCA and LAD arteries. These findings demonstrate that endurance exercise training increases EDD in the BR and FEM arteries, but does not alter the development of atherosclerosis in HH swine. Supported by NIH HL083597 , HL36088 and HL52490