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Pharmacokinetics of alpha‐lipoic acid in dogs
Author(s) -
Gross Kathy Lynn,
Zicker Steven C.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1117.5
Subject(s) - pharmacokinetics , meal , latin square , capsule , dosing , medicine , bioavailability , factorial experiment , oral administration , zoology , pharmacology , chemistry , mathematics , food science , biology , rumen , botany , statistics , fermentation
The objective of this study was to evaluate effect of dose and method of delivery on pharmacokinetics of orally administered dl‐alpha‐lipoic acid (ALA) in 27 healthy dogs. Three different doses of ALA (2.5, 12.5 or 25 mg/kg bodyweight) and three variations of oral administration were evaluated (capsule form after 12 hours of fasting, capsule form given with a food meal (control food), co‐manufactured in the process of a complete extruded food meal). The control food without ALA was fed throughout the study period. A three period Latin square design was used to create a 3x3 factorial arrangement of treatments with dogs assigned to a group following a planned treatment assignment. Serum was collected at 1 minute before ALA dose and 15, 30, 45, 60 and 120 minutes after ALA dosing. Pharmacokinetic parameters were calculated using a non‐compartmental model and analyzed using non‐parametric tests of WinNonlin 4.1 in SAS v9.1. There was a significant effect of dose for all delivery methods (P<0.05). In addition, there was a significant effect of delivery method (p<0.05) with ALA incorporated in a food meal resulting in lower maximum serum concentrations and area under the curve.