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Effects of cholesterol diet and excercise on lipid level, liver function, platelet aggregation and erythrocyte Na+ efflux in rats
Author(s) -
Kang Min Sook,
Kim Jung Lye,
Kang Young Hee,
Kang Jung Sook
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1116.9
Subject(s) - medicine , endocrinology , triglyceride , cholesterol , chemistry , platelet , biology
Present study was conducted to investigate the effects of exercise and cholesterol diet on plasma and liver lipid profile, platelet aggregation, erythrocyte Na efflux and liver index such as GOT and GPT using rats on 0.5% cholesterol diet and/or treadmill for 6 weeks. L.W./B.W. ratio was significantly increased in groups fed cholesterol diet (p<0.01), but exercise tend to decrease this ratio. Plasma total and LDL‐cholesterol was significantly increased and HDL‐cholesterol was decreased in groups with cholesterol diet (p<0.01). Plasma triglyceride was significantly decreased in both groups fed cholesterol diet compared with groups fed normal diet (p<0.01). Exercise decreased plasma triglyceride and showed a significant difference between two groups fed normal diet (p<0.01). Liver total cholesterol and triglyceride was significantly increased in groups fed cholesterol diet (p<0.01), but exercise did not affect on these levels. Intracellular Na and total Na efflux were not different, but Na‐K ATPase tend to increase in groups with exercise. Hematocrit was significantly lower (p<0.05) in group of cholesterol diet without exercise compared with other groups. Platelet aggregation in both the initial slope and the maximum was increased in groups fed cholesterol diet, but not statistically significant. Liver index of both GOT and GPT was significantly increased in groups fed cholesterol diet (p<0.01), and exercise significantly (p<0.01) decreased both GOT and GPT especially in groups fed cholesterol diet when compared with their non exercising partners. This study showed that cholesterol diet increases plasma and liver lipid and GOT and GPT, and exercise improves plasma and liver lipid profile and liver index of GOT and GPT preventing fatty liver.