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Experimental animal model to study of diet supplementation with phosphorylated alpha glucomannan polysaccharide
Author(s) -
Lindemann Garrett W,
Guerrero Antonio,
AlonsoLebrero Jose L,
ValdesHevia Marta D,
Brieva Aurora,
Reyes Eduardo,
Griffin Cristina E
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1116.10
Subject(s) - glucomannan , broiler , weight gain , bacitracin , body weight , feed conversion ratio , zoology , feed additive , medicine , biology , food science , antibiotics , biochemistry
The WHO has recommended that antibiotics not be used for growth promotion in feed animals. The purpose of this study was to compare the efficacy of Candida utilis alpha phosphoglucomannan (GLPH‐1) to a commercially available bacitracin (BMD60) in broiler chickens. A three hundred forty five poultry study was conducted with Ross x Ross male broiler chickens to evaluate the efficacy of GLPH‐1 to a commercially available BMD60 at a sub‐therapeutic level in a production setting. On study days 7, 14 and weekly there after food intake per pen and individual body weights were collected for the determination of body weight gain. We found that GLPH‐1, feed at 1 mg per kg body weight, as a growth promoting additive increased body weight and gain by 2.87% and 3.10% respectively. The use of GLPH‐1 is not associated with increased mortality. In the group treated with diet including BMD60, as a growth promoting additive, suffered a reduced accumulated survival at 15, 21 and 49 days of treatment of 84.34%, 80.00% and 78.26% respectively as well as suffered a diminished percentage of body weight and weight gain with respect to the group treated with a diet not containing any growth promoting additive (−3.72% and −4.03% respectively). The main finding of this study was that a substantial improvement in chicken mortality and body weight gain in the presence of GLPH‐1. GLPH‐1 is also a good growth promoting additive, safe and efficacious.