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Effects of red ginseng ethanol extract on lipid metabolism in C57BL/6J mice fed high‐fat diets
Author(s) -
Mun EunGyeng,
Kim MinA,
Kim YoungSook,
Wee JaeJoon,
Cha YounSoo
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1112.1
Subject(s) - ginseng , triglyceride , chemistry , lipid metabolism , ethanol , endocrinology , blood lipids , obesity , medicine , cholesterol , food science , biochemistry , biology , alternative medicine , pathology
This study evaluated the effects of supplementation of red ginseng ethanol extract (RG‐EtOH; 0.1%, 0.5%, and 1% of high‐fat diet) in C57BL/6J mice fed high‐fat diet (60% fat kcal) for 8 weeks. The RG‐EtOH diet groups did not show any difference in food and energy intakes compared with the high‐fat diet group, but had lower final body weights, epididymal, and back fat pad weights. Triglyceride and total cholesterol concentrations of RG‐EtOH diet groups in serum were significantly lower than high‐fat diet group. Higher concentrations of RG‐EtOH, however, did not have greater effects on serum lipid profiles. Although the 1% concentration of RG‐EtOH group had lower lipid profiles and fat pad weight than high‐fat diet group, the effect was not as great as in the 0.5 percent of RG‐EtOH. These results were confirmed by mRNA expressions of enzymes (ACS, CPT‐I, PPAR‐α, PPAR‐γ, and ACC) which are related to lipid metabolism by reverse transcriptional‐PCR. We suggest that 0.5% RG‐EtOH is the most effective dose for improving lipid metabolism. Also, our study show that red ginseng ethanol extract reduced obesity induced by high‐fat diets. (This study was supported from the KT&G Central Research Institute.)