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Protective Effect of Ginseng and Several Medicinal Herbs on Heat Stress by IFIT1 and IFIT2 Gene Expression
Author(s) -
Yoon Kye Yoon,
Kim KuiJin,
Lee HeeHyun,
Hong HeeDo,
Lee BooYong
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1108.5
Subject(s) - ginseng , heat stress , medicinal herbs , chinese herbs , immune system , traditional medicine , gene expression , medicine , biology , gene , traditional chinese medicine , pathology , immunology , biochemistry , zoology , alternative medicine
Ginseng and several medicinal herbs are known to enhance stamina and immune function, it has been suggested to have pharmacological activities in the cardiovascular, endocrine, immune, and central nervous systems. Heat stress can trigger a cellular stress response characterized by induction to against heat environment. IFIT1 and IFIT2, which are bound to the translation initiation factor eIF3, inhibit translation of cellular stress response. Rats divided to 6 groups and were adapted at room temperature for four weeks. One group was raised at room temperature condition, another group was raised at heat stress condition for two weeks (38°C, 5hr/day), the others were administrated with ginseng and medicinal herbs on heat stress condition. To investigate protective effect of ginseng and medicinal herbs on heat stress, expression level of IFIT1 and IFIT2 mRNAs of rat liver examined by RT‐PCR and real‐time PCR. Compared to unstressed controls, the expression level of genes was generally increased in the heat stressed rats. But the expression levels of IFIT1 and IFIT2 of groups, which were administrated with ginseng and medicinal herbs, was decreased more than those of group which was only stressed by heat. In conclusion, ginseng and several medicinal herbs are effective on protecting rat against heat stress.