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Associations between vitamin K and circulating cytokines in older men and women
Author(s) -
Shea M. Kyla,
Dallal Gerard E.,
DawsonHughes Bess,
Ordovas José M.,
O’Donnell Christopher J.,
Gundberg Caren M.,
Peterson James W.,
Booth Sarah L.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1106.1
Subject(s) - osteoprotegerin , medicine , endocrinology , osteocalcin , proinflammatory cytokine , bone remodeling , vitamin , c reactive protein , vitamin d and neurology , bone mineral , interleukin 6 , inflammation , osteoporosis , biology , alkaline phosphatase , activator (genetics) , biochemistry , receptor , enzyme
Vitamin K modulates cytokines involved in bone turnover in vitro, suggesting an alternative mechanism by which vitamin K may affect skeletal health. In 379 men and women (60–80y, 59% F) participating in a double‐blind randomized controlled trial (RCT) to assess the effect of phylloquinone supplementation on bone mineral density (BMD), we examined cross‐sectional associations between measures of vitamin K status[plasma phylloquinone and serum % undercarboxylated osteocalcin (%ucOC)] and interleukin‐6 (IL6), osteoprotegerin (OPG), and C‐reactive protein (CRP) concentrations at baseline, and the effect of 3‐years of daily 500mcg phylloquinone supplementation on circulating cytokines. Cross‐sectionally, plasma phylloquinone was inversely associated with IL6 and CRP (p<0.05); %ucOC was positively associated with IL6 (p<0.05). OPG was associated positively with plasma phylloquinone and inversely with %ucOC (p<0.05). IL6, OPG, and CRP concentrations did not differ after 3 years between individuals who received phylloquinone supplementation and those who did not. There was no association between the 3‐year changes in circulating cytokines and BMD. That the baseline cross‐sectional associations between vitamin K status and circulating cytokines were not supported in a 3 year RCT may suggest that vitamin K status is reflective of healthy lifestyle patterns that influence inflammation.