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Gamma Tocopherol alone and in Combination with Alpha Tocopherol Decreases Biomarkers of Oxidative Stress and Inflammation in Subjects with Metabolic Syndrome
Author(s) -
Devaraj Sridevi,
Leonard Scott,
Traber Maret G,
Jialal Ishwarlal
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1103.8
Subject(s) - oxidative stress , medicine , endocrinology , alpha tocopherol , placebo , inflammation , metabolic syndrome , vitamin e , nitrotyrosine , isoprostane , alpha (finance) , antioxidant , diabetes mellitus , lipid peroxidation , chemistry , biochemistry , nitric oxide , nitric oxide synthase , surgery , construct validity , patient satisfaction , alternative medicine , pathology
Metabolic syndrome (MetS) is associated with increased incidence of diabetes and cardiovascular disease (CVD). Prospective clinical trials with alpha tocopherol (AT) have been equivocal. AT supplementation decreases circulating gamma tocopherol (GT), thus, we tested supplementation with GT (800 mg/day), AT ( 800 mg/day), the combination or placebo for 6 weeks on AT and GT concentrations, biomarkers of oxidative stress and inflammation in MetS subjects (n=20/group). Plasma AT and GT levels increased following supplementation with AT alone, GT alone or in combination. AT supplementation significantly decreased GT levels. Urinary alpha and gamma CEHC, metabolites of the respective Ts also increased correspondingly, with the combination resulting in significant increases in both compared to placebo. HsCRP significantly decreased in the combined AT +GT group (p<0.05). There was a significant decrease in TNF with AT alone or in combination with GT. Plasma MDA/HNE and lipid peroxides were significantly decreased with AT, GT alone or in combination (p<0.01). Nitrotyrosine levels were significantly decreased only with GT or GT+AT but not with AT (p<0.01). Thus, the combination of AT and GT supplementation appears to be superior to either alone on biomarkers of oxidative stress and inflammation and needs to be tested in prospective clinical trials to elucidate its utility in CVD prevention.