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ADENOSINE DEAMINASE: AS INDICATOR OF NUTRITIONAL STATUS.
Author(s) -
Feliu Maria Susana,
Perris Paula,
Slobodianik Nora
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1102.2
Subject(s) - adenosine deaminase , anorexia nervosa , medicine , body mass index , depression (economics) , immune system , adenosine , anorexia , gastroenterology , endocrinology , immunology , eating disorders , psychiatry , economics , macroeconomics
Previous papers in thymocytes' suspensions of rats, point out to the activity of Adenosine Deaminase(ADA) as potential marker of nutritional status. Moreover, some authors have verified its increase in serum of patients with pathologies related with lymphocytes T. Therefore, subjects with nutritional disorders have shown depression of the immune system, evaluated through immunological markers. So, we analyze if serum ADA activity on populations in nutritional risk, could be considered functional biochemical parameter. The study included 26 women with anorexia nervosa (AN, 14–32 years, , Body Mass Index (BMI)Kg/m 2 : 17.9±1.8); 33 obese children of both sexes (O, 5–13 years, , (BMI:Kg/m 2 : 27.4±4.3) and 16 children with cystic fibrosis (CF, 5 months‐9 years).; the activity of ADA (U/L) was determined by the method of Giusti and Galanti. Groups were compared with the respective age‐match well‐nourished control(C), applying the test of Student. The results expressed as X± SD (UI/L) were: AN: 25.7±8.2*vs. 21.0±4.6(n=22); O: 27.1±9.1*vs. 23.0±5.6(n=48); CF: 36.3±15.8*vs. 23.0±5.6 (n=48) It was observed an increase in the activity of ADA at a level of p<0.02 in all groups. These findings reinforce the hypothesis to propose the determination of serum ADA activity in the nutrition studies, as a functional indicator related to the mechanisms of defense. Supported by University of Buenos Aires (B060)