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Tracing Cell Lineage in Mammalian Cardiovascular Development
Author(s) -
Sucov Henry M.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.11.2
Subject(s) - lineage (genetic) , retinoic acid , cell lineage , biology , microbiology and biotechnology , receptor , mutant , cell , computational biology , cellular differentiation , genetics , gene
As is true for most developing tissues and organs, cardiovascular development involves interactions between cells of different lineage origins, which in many cases migrate to their ultimate positions from distant locations. We have utilized Cre/lox approaches for mapping cell lineage contributions to the cardiovascular outflow tract during normal mouse development, and have combined these approaches with conventional and conditional mutant backgrounds to explore the roles of retinoic acid and TGFb receptors during these processes.