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Relationships of smoking and alcohol consumption on atherogenic index, antioxidant status and lymphocyte DNA damage in Korean men
Author(s) -
Oh Hye Sun,
Kim Hyun Young,
Lee HyeJin,
Park Yoo Kyoung,
Kang MyungHee
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1092.6
Subject(s) - lipid peroxidation , comet assay , antioxidant , dna damage , vitamin e , alcohol , population , lymphocyte , medicine , chemistry , vitamin c , physiology , endocrinology , toxicology , biology , biochemistry , dna , environmental health
The purpose of this research was to investigate the influence of alcohol consumption and smoking habits on atherogenic index, antioxidant enzymes, level of lipid peroxidation and lymphocyte damage. The participants included 386 men 19–60 years of age. The level of lipid peroxidation was measured as the level of conjugated diene (CD) and the lymphocyte DNA damage was measured by COMET assay. In the observed sample population, we categorized the subjects into 15 groups. Subjects were divided into 5 groups: A0 (0 g/day, n=49), A1 (1–70 g/day, n=98), A2 (71–140 g/day, n=84), A3 (141–350 g/day, n=101), A4 (>350 g/day, n=40), and then were further divided into S0 (nonsmoker, n=92), S1 (1–15 cigarettes/day, n=138), S2 (>15 cigarettes/day, n=142) depending on the level of cigarette consumption. Regardless of the alcohol intake, there was a continuous increase of the atherogenic index with the increasing quantity of cigarette smoking. HDL‐C was increased with the increasing level of alcohol consumption. In addition, regardless of the alcohol intake, CD level was lowest in the S0 groups and highest in the S3 groups. Antioxidant status measured by plasma tocopherol, carotene and vitamin C level did not differ significantly among groups. The DNA damage (assessed by tail DNA) was greatest in the heavy smokers compared to the non‐ or light smokers. Our result showed that the exposure of cigarette smoking has higher impact on the level of antioxidants and DNA damage than the combined effect with alcohol consumption. This study was supported by a grant from Kyung Hee University Research Fund in 2004 (KHU‐20040945)