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Diacylglycerol consumption and blood lipids and adiposity in rats
Author(s) -
DeIulio Emily,
Precht Kristy,
Zamudio Abigail,
Nemoseck Tricia,
Stocker Kelly,
Kern Mark
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1092.10
Subject(s) - weanling , coconut oil , diacylglycerol kinase , chemistry , triglyceride , cholesterol , blood lipids , endocrinology , medicine , zoology , food science , biochemistry , biology , protein kinase c , enzyme
Diacylglycerol (DAG) rich oil can promote lower adiposity and concentrations of serum triglycerides (TG) compared to triacylglycerol (TAG) rich fats. Most research, however, has assessed the influence of DAG fed at relatively high levels rather than the moderately low amounts evaluated here. Sixteen male weanling Sprague‐Dawley rats were equally divided into two groups. Rats consumed diets consisting of 21% fat by weight, mainly from coconut oil. DAG replaced 4% of the coconut oil for one group. After 30 days, serum total cholesterol (TC), HDL‐C, TG, glucose, and epididymal fat pad weights were assessed. Food intake (428 ± 46 vs. 457 ± 45 g), weight gain (184 ± 20 vs. 189 ± 15 g), food efficiency ratio (0.43 ± 0.05 vs. 0.41 ± 0.04), fat pad weights (2.740 ± 0.822 vs. 2.811 ± 0.488 g), TG (41.0 ± 20.0 vs. 51.3 ± 10.3 mg/dl), TC (78.7 ± 14.0 vs. 80.7 ± 18.8 mg/dl), and glucose (160.8 ± 31.1 vs. 169.8 ± 41.7 mg/dl) were similar (p>0.05) between the DAG and coconut oil fed rats, respectively. HDL‐C concentration (43.8 ± 6.0 vs. 56.5 ± 5.8 mg/dl) was lower for DAG‐fed rats (p<0.05). Results suggest that consuming a diet containing excess levels of saturated fat with moderately low amounts of DAG does not significantly improve lipids or reduce fat storage and may actually lower HDL‐C. Researchers should examine the minimum amount of DAG required to elicit positive responses and as a part of what type of diet the effects are most pronounced.