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Carcass energy content and adiposity in response to diet energy levels and moderate exercise in diet‐induced obese and non‐obese rats
Author(s) -
Vander Tuig Jerry G.,
Chi Myung S.,
Taylor Veronica,
Galbreath Karen
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1090.8
Subject(s) - medicine , endocrinology , obesity , weight gain , treadmill , zoology , body weight , biology
Various animal models are used to study development of obesity. Diet‐induced obesity (DIO) in animals fed high‐energy diets is comparable to development of human obesity. This study examined effect of exercise and diet energy levels on carcass energy and fat depots in DIO rats. Six‐week‐old male Sprague‐Dawley rats (185 ± 2 g, mean ± sem) had unlimited access to high‐fat diet (38% kcals from fat) for 12 weeks. Rats from greatest and least weight gain quartiles (445 ± 5 and 334 ± 4 g) were assigned to DIO and non‐obese, diet‐resistant (DR) groups, respectively. For 10 weeks, DIO and DR rats had unlimited access to high‐fat (38% of kcals) or low‐fat (12% of kcals) diet and were exercised or kept sedentary in a 2 × 2 × 2 design (obesity × diet × exercise). Exercise consisted of treadmill running with weekly increases in speed and duration to values of 15 m/min and 1 hr/day for the final 2 weeks. Exercise reduced (p<0.05) weight gain and total carcass energy (22% and 24%) but did not affect energy intake of DR rats fed low‐fat and high‐fat diets. In DIO rats, exercise and low‐fat diet reduced weight gain and energy intake (12%) but did not affect (p>0.05) carcass energy. Exercise reduced epididymal fat weight by 42% and 31% in DR (both diets) and by 25% in DIO rats fed low‐fat diet only. Moderate exercise more effectively reduced carcass energy and fat in DR rats than in DIO rats, primarily when DIO rats were fed high‐fat diet. Supported by USDA/CSREES.