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Fluid distribution changes after gastric bypass surgery
Author(s) -
Dobratz Jennifer R,
Sibley Shalamar D,
Beckman Tiffany R,
Lautenschlager Lauren M,
Kellogg Todd A,
Ikramuddin Sayeed,
Earthman Carrie P
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1090.6
Subject(s) - extracellular fluid , medicine , weight loss , body water , gastric bypass surgery , body mass index , gastric bypass , fluid compartments , surgery , body weight , urology , gastroenterology , obesity , anesthesia , chemistry , extracellular , biochemistry
Obese individuals have a relative expansion of extracellular water (ECW), otherwise expressed as an elevated ECW/intracellular water (ICW) ratio. These aberrations do not necessarily normalize after weight loss. The aim of this research was to investigate fluid distribution abnormalities in extremely obese individuals, and to evaluate changes after weight loss induced by gastric bypass surgery. Fifteen extremely obese women (body mass index: 48.9 ± 7.0 kg/m2; age: 48.4 ± 9.2 years) were assessed for fluid distribution before gastric bypass surgery (T1), and approximately 1 week (T2), 6 weeks (T3), 6 months (T4), and 1 year postoperatively (T5). ECW and TBW were measured by bromide and deuterium dilution, respectively, and ICW was determined by subtraction. Changes in body water parameters were compared over time by ANOVA. Over the course of the study, ICW decreased by 5.72 ± 3.20L (P< 0.001), and ECW did not change (P=0.617). The ECW/ICW ratio increased by 0.32 ± 0.24 (P< 0.001). Post‐hoc comparisons revealed significant ECW/ICW changes from baseline to each post‐operative time point (P<0.05) except T2. These preliminary data are similar to other published reports, and suggest that the relative expansion of ECW does not normalize, and may in fact worsen after weight loss. Contributing factors should be evaluated.