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Hydroxypropyl methylcellulose, a viscous indigestible polysaccharide, reduces adiposity and lowers plasma leptin and resistin concentrations in rats
Author(s) -
Islam Ajmila,
Hesslink Robert L.,
Gallaher Daniel D.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1090.2
Subject(s) - leptin , endocrinology , medicine , resistin , chemistry , adiponectin , polysaccharide , adipokine , adipose tissue , insulin , biology , obesity , biochemistry , insulin resistance
Previous studies in this laboratory have suggested that viscous indigestible polysaccharides reduce adiposity with little or no effect on body weight. To further understand this effect, we have examined the effect of a viscous indigestible polysaccharide, hydroxypropyl methylcellulose (HPMC) on body composition and plasma adipokines in rats. Male Wistar rats were fed either a cellulose based control diet (no viscosity) (n = 12) or HPMC‐containing diet (high viscosity) (n = 24) for 6 weeks. Body composition was measured by dual X‐ray absorptiometry (DEXA) before and after 6 weeks of feeding. Rats fed the HPMC diet had a high intestinal contents viscosity whereas rat fed cellulose diet had no intestinal contents viscosity. After statistically adjusting for slight differences in final body weight, rats fed HPMC had significantly reduced body fat mass and greater lean body mass than the cellulose group, based on DEXA scanning and lower weights of epididymal and perirenal fat pads. Rats fed HPMC had significantly lower fasting plasma leptin and resistin concentrations. However, plasma adiponectin levels did not differ between the groups. There were no significant differences between groups in fasting plasma glucose or insulin levels. These results indicate that viscous indigestible polysaccharides reduce adiposity independent of an effect on body weight. (Supported by Imagenetix Inc.)