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The metabolic responses to protein preload with high or low whey content.
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1090.13
Subject(s) - peptide yy , appetite , preload , crossover study , whey protein , food science , endocrinology , chemistry , medicine , zoology , biology , hemodynamics , placebo , receptor , alternative medicine , pathology , neuropeptide y receptor , neuropeptide
Previous studies have shown that protein is more satiating than carbohydrate or fat, although the precise mechanisms are unclear. The aim of this study was to investigate the effects of liquid preloads with different whey protein content on subjective ratings of appetite and metabolic profile. Twelve lean, healthy men attended two trials in a randomised crossover design. Subjects arrived in the laboratory after an overnight fast and consumed a standardized breakfast. At approx 11am they were provided with one of two 250 kcal preloads (containing either 10 or 20% energy from whey protein). Appetite ratings were collected every 30 min using visual analogue scales (VAS), and arterialised blood samples every 15 min for 90 min. There were no differences in the VAS appetite ratings. The high protein preload produced a lower glyceamic and insulemic response, sustained the increase in glucagon like peptide‐1 (GLP‐1) and polypeptide YY (PYY) and produced greater increase in plasma amino acid profiles. Thus, foods with higher whey protein content may enhance satiety by altering the metabolic and gut hormone profile. This study was funded by a BBSRC CASE PhD Studentship with Mars UK as Industrial Partner.