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The associations of apoB/apoA1 ratio, insulin resistance and metabolic syndrome in Korean type 2 DM patients
Author(s) -
Lim Hae Mi,
Kim Jung Eun,
Sook Lee Hyun,
Ju Choi Young,
Bum Huh Kap,
Young Kim Wha
Publication year - 2008
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.22.1_supplement.1083.8
Subject(s) - insulin resistance , dyslipidemia , apolipoprotein b , medicine , apolipoprotein a1 , quartile , endocrinology , metabolic syndrome , lipid profile , insulin , obesity , cholesterol , confidence interval
The purpose of this study is to examine the association of apoB/apoA1 ratio, insulin resistance, and MetS in Korean T2 DM patients. Subjects were 812 T2DM patients and were classified into quartiles based on apoB/apoA1 ratio. The prevalence of MetS in Q1(the lowest apoB/apoA1 ratio group) was 25.5% foe male and 39.2% for female, however, in Q4(the highest apoB/apoA1 ratio group) was 71.7% and 84.5% respectively. Subjects in Q4 showed significantly higher MetS prevalence than in Q1 for both gender. Q4 also showed visceral obesity, dyslipidemia, high blood pressure, insulin resistance and inflammatory status than Q1. In female subjects, Q4 showed significantly higher carbohydrate intake, however, significantly lower intakes of protein, lipid, Ca, Fe, Zn, and Vit B2 than Q1(per 1000kcal). Q4 with high insulin resistance showed significantly higher MetS prevalence than Q1 with low insulin resistance for both gender. In conclusion, high apoB/apoA1 ratio with insulin resistance significantly associated with MetS in T2DM patients and it seems that nutrient intake play a role especially in female subjects.(This work was supported by second stage of BK21 project in 2007 and by Seoul R&BD. Program, NO. 10526)